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For patients who have a more aggressive disease or what we call moderate to severe activity, methotrexate alone might not be adequate, Dr

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Ultimately, disulphide-reduced, metal-free SOD1 accumulates in amorphous and fibrillar aggregates in the cytoplasm and mitochondria of neurons and astroglia of ALS patients and mutant SOD1 transgenic mice 10,11,40

J Proteome Res 2022