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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

The paper highlights the advantages of solid-phase methods in enabling efficient, scalable, and rapid production of PROTACs, streamlining the synthesis process for drug discovery

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Hosokawa R, Urata MM, Ito Y, et al

Specifically, it is necessary to determine how NNMT promotes fat accumulation in adipose tissues while managing fat accumulation in livers caused by nutrient overload (Trammell and Brenner, 2015)

Benztropine acts in the central nervous system (CNS) and smooth muscles by competing with acetylcholine at muscarinic receptors, reducing central cholinergic effects, which alleviates PD symptoms