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Almquist et al., Hyaluronic acid-based activatable nanomaterials for stimuli-responsive imaging and therapeutics: beyond CD44-mediated drug delivery

APX and GR are the key enzymes of the AsAGSH cycle

Evaluation of Pharmacodynamic Response Improvement due to Increased Drug Delivery The final aim of the transporter-mediated drug delivery approach is to increase the concentration of the delivered drug at the target site in the brain, resulting in higher pharmacological response