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Through conjugation reactions, glutathione binds to toxins, drugs, and metabolic byproducts, transforming them from fat-soluble compounds that accumulate in tissues into water-soluble forms that can be easily eliminated through urine and bile

5-Amino-1MQ is an orally bioavailable, cell-permeable small molecule that potently inhibits NNMT (nicotinamide N-methyltransferase), the enzyme responsible for methylating nicotinamide to 1-methylnicotinamide (1-MNA)

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it directly reduces H 2 O 2 and hydroxyl radicals, effectively neutralizing these harmful oxidants (Figure 2)

Monoamines are highly unstable, chemically reactive molecules , any unbound cytoplasmic neurotransmitter is highly prone to auto-oxidation in the cytosol (Lohr et al., 2014

[DOI] [PMC free article] [PubMed] [Google Scholar] 230.Aich A., Freundlich M., Vekilov P.G