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A major part of the systemic dose will form mixed disulphides together with serum albumin, while a minimal amount of the drug fractions will undergo hepatic metabolism to become disulphides

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The effect of copper on the GM has also been demonstrated in Nile tilapia, where exposure to subacute levels (0,5 mg/L, 1 mg/L and 2 mg/L Cu 2+ ) for 14 days resulted in reduced bacterial diversity, a decreased abundance of Ruminococcus and Shigella and increased abundance of Edwardsiella and Aquabacterium (Zhang et al., 2022a)

Arch Biochem Biophys 516 , 146153 (2011)

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[161] found that HCQ treatment significantly decreased TC and the AS index while increasing HDL cholesterol levels in pSS patients