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Much of the purported clinical utility is derived from anecdotal accounts or small, uncontrolled series, rather than from robust randomized trials

Many patients with diagnosed deficiency find their symptoms significantly improve after targeted supplementation, with over 90% reporting positive changes within a few months of treatment

Limited Western clinical evidence

10.1016/j.molcel.2021.08.021 52 SegrefA.Kevei.PokrzywaW.SchmeisserK.MansfeldJ.Livnat-LevanonN.et al (2014)

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Ongoing research continues to evaluate sterile solvent systems and preservative-containing aqueous solutions in controlled laboratory environments, including their influence on experimental reproducibility and contamination prevention