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HGF/c-Met signaling is a well-established oncogenic pathway: c-Met is amplified or overexpressed in multiple cancers (gastric, lung, renal, hepatocellular) HGF/c-Met activation promotes tumor cell proliferation, survival, invasion, and metastasis c-Met inhibitors are FDA-approved cancer drugs (cabozantinib, crizotinib, capmatinib) A compound that potentiates HGF/c-Met signaling raises theoretical concerns about promoting tumor growth or transformation with chronic use

F., Almohmadi, N

This pharmacological distinction is important for researchers designing experiments that depend on sustained versus transient receptor activation

Transl Psychiatry 13:88

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Always remember that the goal is to have as clean and safe a container as possible for your long-term water storage