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Dismutation of O 2 (either spontaneously or, at a significantly faster rate, through a reaction catalyzed by MPO itself [90]) gives rise to oxygen and H 2 O 2 , the latter being a precursor of one of the most powerful naturally occurring oxidants, the hydroxyl radical (OH)

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Moreover, the C-terminal serine of the peptide was replaced by cysteine via site-directed mutagenesis performed with polyethylene glycol

& Koonin, E

World J Gastroenterol (2021) 27(28):465366

That's September of 2023