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Almost all patients using topical tretinoin reported skin irritation such as peeling, xerosis (dry skin), burning, stinging, erythema, and pruritus

doi: 10.2337/diacare.22.10.1626

however, the small sample size does not provide any definite conclusion [115]

Adding retatrutide changes the metabolic environment significantly

Still, it matters

This work was supported by AMED Grant Number JP21zf0127001 (T.S.), JST, CREST Grant Number JPMJCR2123 (T.S.), MEXT KAKENHI Grant Number JP23H04946(T.S.) and World Premier International Research Center Initiative (WPI), Human Biology-Microbiome-Quantum Research Center (Bio2Q) (T.S.), MEXT, Japan