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Lushchak, 2014)

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TNFRSF14 influences the activation state of these glial cells through its unique signal transduction mechanism, which in turn contributes to the development of neuroinflammation and the protective processes of nerve cells .Studies have found that the continuous activation of TNFRSF14 may trigger chronic neuroinflammation, which is closely related to the disease progression of MS 47

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Initially, it was hoped that the combination would protect both drugs against the development of resistance, but unfortunately, that has not been the case [81, 82], so novel approaches are needed

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