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In the recent years, the CRISPR-dCas9 system is poised to become the most promising targetable epigenome-editing tools

doi:10.1002/jcp.27570

doi: 10.1038/bjc.2015.221 54 XingWLiYChenJHuQLiuPGeXet al

H., Buraggi, G

Overexpression of growth factors like VEGF, EGF, and IGF activates the PI3K-AKT-mTOR signaling pathway by binding to RTKs on tumor cells, regulating HIF- expression and translation, and causing its accumulation (184186)