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The long term outcomes for recipients of deceased donor liver transplants showed graft failure rates of 15.0% at 3 years for transplants done in 2018, 20.7% at 5 years for transplants done in 2016, and 38.5% at 10 years for transplants done in 2011

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The lack of oxygen-carrying red blood cells can also affect the functioning of various organs in the body

1993 reported increased protein synthesis in rat skeletal muscle with LR3-IGF-1 administration

showed that in cultured rat ventricular myocytes, trimetazidines beneficial effects were only observed when cells were undergoing hypoxia and not during normoxia, highlighting trimetazidine as a metabolic regulator that would not increase mitochondrial function in healthy states [123]

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