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doi: 10.1016/S0006-3223(02)01329-X 103 PatakPWillenbergHSBornsteinSR

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Effects of Valproate on Other Drugs Valproate has been found to be a weak inhibitor of some P450 isozymes, epoxide hydrase, and glucuronosyltransferases

Significant patient-centered benefits encompass: Minimal risk of substance dependency Reduced side effect profiles Greater flexibility in treatment planning Enhanced patient autonomy in mental health management By offering a comprehensive yet gentle approach to mental health treatment, trazodone represents an important advancement in pharmaceutical intervention