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copper activates hypoxia-inducible factor (HIF)-1, and when copper is chelated, HIF-1-mediated VEGF expression is blocked (164,165)

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4.5 Obesity-associated bronchial vascular airway remodeling in asthma Several key factors are implicated in the initiation and progression of bronchial vascular remodeling, including the pro-inflammatory cytokines (309311), angiopoietin (312, 313), and growth factors specifically VEGF (314316)