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10.1093/ajcn/80.3.539 34 DambrovaM.LatkovskisG.KukaJ.StreleI.KonradeI.GrinbergaS.et al (2016)

Liver IGF-1-deficient mice show a reduction of around 75% in circulating IGF-1 levels and as a consequence due to the lack of negative feedback, these mice have about a fourfold increase in GH production