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OCA treatment ameliorated high-fat diet (HFD)-induced dysplasia, potentially by reducing deleterious secondary BAs (e.g., DCA, TDCA), decreasing microbial bile salt hydrolase (BSH) expression, and favorably reshaping the tumors immune landscape (128), thereby potentially reversing an immunosuppressive TIME

doi: 10.1021/acs.est.5b06069 40

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The specificity of AIF and AIF3 RNA probes was verified in human cell line MDA-MB-231 expressing endogenous AIF or CRISPR/Cas9-produced AIF3 (Supplementary Fig