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Riggs and others defined epigenetics as the genetic changes caused by mitosis or meiosis in the function of genes without changing the genetic sequence

More recently, others have found elevated expression of the NAD + glycohydrolase enzyme CD38 in the ovary during reproductive ageing, and showed that blocking the degradation of NAD + through small molecule inhibition of CD38 can prolong female reproductive lifespan (Perrone et al, 2023

Van Keer S, van Splunter AP, Pattyn J, De Smet A, Herzog SA, Van Ostade X, et al

That is the dogma of the situation we're in

Alterations of the TJ complexes can increase paracellular permeability and pathogen translocation that can induce sustained activation of the mucosal immune system and tissue damage