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Inside the mitochondrial matrix, the acyl group is transferred back to CoA by carnitine palmitoyltransferase II (CPT-II), allowing the fatty acid to enter the -oxidation cycle

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As reported, SIRT1 deacetylates the p65 subunit of NF-B at lysine 310 (Lys310), thereby inhibiting its transcriptional activity and attenuating the expression of pro-inflammatory genes [37]

[DOI] [PMC free article] [PubMed] [Google Scholar] 176.Sun N, Youle RJ, Finkel T