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Authors' contributions YCL conceived the study, wrote the manuscript and prepared the figures

After the binding reaction, the unbound aptamers were removed by 5 washing steps with 500 L of the B/W buffer

Therefore, extensive future research is needed to address these issues and improve the delivery and patient experience [151, 190]

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In autoimmunity, there is a polar shift or dominance of either the TH-1 or TH-2 system and one side of the system becomes overactive or dominant

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