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HIF1alpha-dependent uncoupling of glycolysis suppresses tumor cell proliferation

[0339] The compound of Formula la at 100 mg/mL in water with 0.1% w/v HPMC, 0.5% w/v poloxamer 237, and 0.9% sodium chloride: The suspension vehicle containing the excipients HPMC, poloxamer 237, and sodium chloride was prepared as described above in Example 3

Other important constituents also include several isoflavonoid derivatives such as shinpterocarpin, glabrone, glabridin, galbrene, lico-isoflavones A and B (Asl and Hosseinzadeh, Figure 9 Due to their antioxidative properties, several species of Glycyrrhiza were investigated for possible therapeutic effects as neuroprotectants against neurodegenerative disorders such as PD, AD, and dementia

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Notably, the optimal in vivo neuroprotective dose was identified as 0.5 mg/kg, which produced substantial behavioral and histological improvements

As outlined in Section 5.1, complementary strategies utilizing hypoxia-preconditioned cells and their derivatives may further potentiate these regenerative processes, highlighting the need for precise regulation to prevent maladaptive outcomes