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The risk-benefit should be reassessed periodically in patients who receive indefinite anticoagulant treatment.12,20The dose of warfarin should be adjusted to maintain a target INR of 2.5 (INR range, 2.0 to 3.0) for all treatment durations

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It has randomized Phase 3 human data in adults with HIV-associated lipodystrophy, where daily tesamorelin reduced visceral abdominal fat