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Sebaceous and sweat gland function decreases, leading to drier, less hydrated skin, and loss of elastic fibers impairs skin pliability (Zouboulis and Boschnakow, 2001

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The commonly used reporter 10xStat92E-GFP (Bach et al, 2007) is composed of five copies of Socs36E intron 1 enhancer element, each of which contains at least two Stat92E-binding sites, and these are fused to a hsp70 minimal promoter and EGFP to detect enhancer activity

Bartoszek A, Makaro A, Bartoszek A, Kordek R, Fichna J, Salaga M

10.1111/gcb.13041 154 SollidJ.NilssonG

Elevated prostaglandins and wider inflammatory signals, including C-reactive protein, track with severity and are implicated in long-term health risks