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In an observational study of 3,414 participants aged 72 to 94 years who were followed for roughly 30 years, those who actively smoked had worse results on hearing tests

Conclusion: In this first-in-human Phase I study, belcesiran was well-tolerated with dose-dependent and reversible effects on serum AAT levels in HVs

doi:10.1038/sj.mp.4000436 PubMed 40

Induction of mild OS in the bladder of rats by intravesical administration of a low dose of H 2 O 2 (0.003%) has been found to cause higher peak voiding pressure and detrusor hyperactivity

Results Patients with RMS and PMS have distinct PRO scores Thirty-three pwPMS and 86 pwRMS completed the PROs questionnaires MusiQol, MFIS, and BDI-II at study inclusion ( baseline )

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