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NF: nuclear factor

These models highlight distinct pathological and temporal features of AD, including early synaptic changes and amyloid accumulation, providing valuable tools for studying disease progression and potential therapeutic targets

Interestingly, it has been previously reported that LMP2A enhances MYC driven lymphomagenesis through activation of the PI3K-pathway (181183), suggesting that activation of PI3K by LMP2A might be an alternative and/or convergent mechanism to the one driven by TCF3 / ID3 mutations

In addition, with the rise of global profiling strategies such as metabolomics, transcriptomics and large-scale proteomics leading to further delineation of the mechanisms of action of vitamin C, future clinical trials may be designed based on more refined rationales

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