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Autism is associated with a deficiency in complexes 3 and 4 of the mitochondrial respiratory chain, leading to an elevated lactate-to-pyruvate ratio

Huh MS, Ivanochko D, Hashem LE, Curtin M, Delorme M, Goodall E, Yan K, Picketts DJ (2016) Stalled replication forks within heterochromatin require ATRX for protection

After around 3 months, the subsequent brain MRI showed involutional changes that were manifested as a brain volume loss in the same areas with evidence of gyri-form laminar necrosis in both parieto-occipital regions without restricted diffusion

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