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Folic acid has been found to reduce the phosphorylation of Tau in SH-SY5Y cells via methylation of the protein phosphatase 2 (PP2A) gene

However, some patients experience primary or secondary failure due to anti-drug antibodies, insufficient drug levels, or individual differences in the immune environment

Beet root extract has been shown in clinical research to improve time-to-exhaustion, lower the oxygen cost of exercise, and enhance cardiovascular efficiency during endurance activity

Table 1 Fat-soluble vitamin immunomodulatory effects in animal cancer

The search explored the following domains relating to TD: prevalence, clinical presentation, known and potential causative agents and risk factors, strategies to minimize development of TD, treatment options, and overall awareness of the condition, with the objective of understanding any unique characteristics, differences, or similarities between TD and its management in Asia compared with the situation in other world regions

Addressing these issues requires a deep interdisciplinary approach involving materials science, bioengineering, and clinical medicine