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Beyond nigrostriatal dopaminergic system degeneration, the disruption of cortico-striatal glutamatergic transmission is considered a core feature of PD pathogenesis 2

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10.1200/JCO.2004.02.168 36 ChanR.ParkK

(2) Microglia phagocytose myelin debris, which is important as myelin debris can inhibit OPC differentiation, while efficient clearance of myelin debris allows for effective remyelination after experimental demyelination in rodents (Kotter, 2006