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[31] Research has found that heavy metals can markedly alter the function and metabolism of many trace elements, including iron, copper, and selenium

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TNF- serves as a soluble toxic medium produced by liver Kuff cells (KC), mediating the inflammation, tumor cell proliferation and apoptosis

HUVECs grown in the 3D model exhibited not only a markedly elevated level of oxidative stress, expressed by an increased level of malondialdehyde and superoxide dismutase activity inhibition, but also an increased inflammatory response with more secretion of IL-1 and IL-6 in response to TNF- when compared to ECs grown on 2D TCPs

Cancer Res 2014