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Impaired mucociliary clearance, which can occur as a consequence of vaping, can lead to mucus accumulation in damaged lung tissue, causing drugs, like bronchodilators or inhaled corticosteroids (ICS), to remain in the airways longer, slowing clearance rate, increasing the local concentration and side effects and ultimately altering its efficacy (Winters et al

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This property prolongs the action potential, widens the QRS complex, and impairs cardiac inotropy

It also improves conditions associated with blood clot risk by lowering high lipid levels, reducing inflammatory signaling, and decreasing oxidative stress (Granito 2024

As a result, the main melanogenesis regulator MITF is elevated after UVR, followed by an increase in other melanosomal proteins such as TYR, TRP-1 and TRP-2, leading to the stimulation of melanogenesis [47]

Cong T, Luo Y, Fu Y, Liu Y, Li Y, Li X