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Compared to the PA group, the use of NAC under the PA environment also led to a partial decrease in intracellular lipid peroxidation levels (Fig

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Additionally, vitamin E can suppress ALOX activity (50)

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Progression to CC significantly increased the hazard of lung cancer (HR: 2.0

For instance, mitochondrial pyruvate carrier 1 (MPC1) knockout promotes the accumulation of lactate and the subsequent lactylation of fatty acid synthase (FASN) at K673, which further inhibits FASN activity and reduces lipid accumulation