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Subjects in the ALA group took ALA (600 mg/day) for 12 weeks, while patients in the placebo group took a similar placebo capsule (containing wheat flour) every day for 12 weeks

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CF airways feature intense inflammation and high H 2 O 2 production from phagocytes (Galli et al., 2012)

First, cells need enough of the antioxidant GSH to cleave thiamine

Because rapamycin, which extends mouse lifespan 31 , can reverse age-related diastolic dysfunction and restore a more youthful metabolome in the aged myocardium 32 , we next evaluated metabolomic changes in Young, Old Con, and Old mAb female-treated hearts

Supplementation with lactate significantly increased cellular lactylation levels, alleviated DON-induced cell death, and we found that supplementation with Nala had a similar effect (Fig