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Scurvy establishes 1 to 3 months after initiating a vitamin C lacking diet

At the level of subcellular compartments, such as the nucleus, mitochondria, lysosomes, endoplasmic reticulum (ER), Golgi apparatus, etc., these perturbations are sensed and activate the corresponding signal transduction pathways to generate the appropriate biological response

Association of low plasma antioxidant levels with all-cause mortality and coronary events in healthy middle-aged men from France and Northern Ireland in the PRIME study