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Although recently emerged cerebrospinal fluid (CSF) -synuclein seed amplification assays have demonstrated high sensitivity and specificity in identifying PD patients 1 , reliable peripheral fluid biomarkers for PD are currently lacking

Given the illegal nature of AAS use in many settings and the ethical impossibility of conducting long-term interventional studies with supraphysiological androgen doses in humans, a substantial proportion of cases likely remain unreported, and the true prevalence of this phenomenon may be underestimated in the existing literature

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The route of administration changes the profile significantly in terms of absorption and risk

The results further indicated metformins induction of reactive oxygen species, which significantly decreased glutathione levels and the ratio of reduced to oxidized glutathione, as well as the transsulfuration metabolite, cystathionine