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BPC-157 is a synthetic pentadecapeptide derived from a protective gastric protein

Hepatic stellate cell promoted hepatoma cell invasion via the HGF/c-Met signaling pathway regulated by p53

This can also recruit Tie2-expressing monocytes (TEMs) and tumor-associated macrophages (TAMs) to promote angiogenesis and disrupt the temporary balance achieved by anti-angiogenic therapy, leading to chaotic and disordered growth of tumor vasculature (181)

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there is no large human RCT for either