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This higher antibody titer may be attributed to higher dietary Se that is reported to have role in alteration of B-cell development, diversion of Th1/Th2 balance towards Th2, 7,9,23 , ability to reduce oxidative stress, enhancement of antioxidant defenses, and promotion of anti-inflammatory cytokine production 24,55

The hormone hepcidin, elevated in chronic inflammation, binds to ferroportin inducing its internalization and degradation, thereby trapping iron within cells such as macrophages and potentiating pro-ferroptotic microenvironments ( In summary, ferroptosis is profoundly influenced by iron regulatory mechanisms centered on IRP/IRE signaling and ferritinophagy

Thiopurines are indicated as steroid-sparing maintenance agents in both Crohns disease and ulcerative colitis, but not as induction agents due to their slow onset of action [26]

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This allows for a deeper understanding of the specific mechanisms by which astrocytes support synaptic function and maintain overall brain energy homeostasis (Chen et al., 2023)

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