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innocua ) or 37 C ( E

539 (American Chemical Society, Washington, DC, 1993)

Sodium bicarbonate or tris-hydroxymethyl aminomethane (THAM) can be used to correct acidosis which, aside from improving hemodynamics, may relieve the inhibition of metabolic enzymes by low pH

In certain cancer types, including gastric, breast, renal clear cell, colorectal and endometrial cancer, and myeloid leukemia, the absence of GPX3 expression often indicates a poor prognosis and the development of resistance to chemotherapy in patients (2)

Real-time polymerase chain reaction (qRT-PCR) Anti-oxidant genes (CAT, SOD, GPx, GSR, GST and HO-1), Nrf-2/Keap-1 and apoptotic markers expressions were appraised by qRT-PCR