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Collectively, substitutions in the m14/m15 region partially compromise the phaseseparation capacity of PIF4 both in vitro and in vivo

Reprod Biol Endocrinol 16 , 5 (2018)

pmid:12973386 56

The significantly higher numbers of peripheral RGCs in the KD + OHT group versus Control are consistent with our previous study that showed the neuroprotective effect of the ketogenic diet in the DBA/2 J model of glaucoma (Harun-Or-Rashid et al., 2018)

Studies in SLC25A19 knockout mice and in carriers of the SLC25A19 mutation, responsible for the Amish lethal microcephaly (MCPHA, see below) show, respectively, virtually undetectable and markedly reduced mitochondrial TPP levels in mouse embryonic fibroblasts and human lymphoblasts (56), which were completely restored upon addition of TPP to the PDH and KGDH complex assay mixtures (56)