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Empagliflozin attenuates cardiac microvascular ischemia/reperfusion through activating the AMPK1/ULK1/FUNDC1/mitophagy pathway

Methionine in turn is required for the synthesis of S-adenosylmethionine, a methyl group donor used in many biological methylation reactions, including the methylation of a number of sites within DNA, RNA, and proteins ( Figure 1 ) (3)

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Generally, yes safety is not the weak point here