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Solution is injected directly into the vein, causing it to collapse and fade over several weeks

Sterol regulatory element-binding protein 2 (SREBP2) acts as the master transcriptional regulator (129): cholesterol depletion triggers the translocation of SCAP-SREBP2 complex to the Golgi, where proteolytic cleavage releases nuclear SREBP2 (nSREBP2) to upregulate cholesterol synthesis genes (e.g., HMGCR, SQLE), cholesterol sufficiency retains the complex in the ER via SCAP-INSIG binding (130)

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