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Most current therapeutic candidates for NDDs face challenges in crossing the bloodbrain barrier, substantially limiting their clinical efficacy (Ross and Poirier, 2004)

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doi: 10.1159/000267704 197 ReddyVNGiblinFJLinL-RChakrapaniB

The bound sulfate, mimicking the cleaved phosphate, is located in an approximate line between the phosphate of ADP and the amide carbon of the GSH CysGly linkage (Figure 2)