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Glutathione reduction is a significant factor in initiating ferroptosis, a type of controlled cell death

doi: 10.1038/nature13489 81 MeintjesG.StekC.BlumenthalL.ThienemannF.SchutzC.BuyzeJ.et al

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10.1038/s41422-020-0282-0 89

Our findings align with previous studies with radical trapping antioxidants, i.e., ferrostatin-1 and liproxstatin-1, in MASLD models

There is no reaction in glycolysis in which carbon dioxide is produced, and this suggests that there must be some other pathway of glucose metabolism in the erythrocyte, in which carbon-1 of glucose is released as carbon dioxide