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Administration of Que at a concentration of 1000 mg/day or more for several months showed no adverse effects in serum electrolytes, renal and hepatic function, blood parameters, or hematology (Ferry et al., 1996)

GPX4 deletion led to neuronal death in the hippocampal area of neonatal and adult mice, along with increased astrocyte activation, indicating that GPX4 serves as a defensive sentinel during nervous-system degeneration processes (Yoo et al., 2012)

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Beyond this global shift, aerobic glycolysis remains active in differentiating neurons and plays a crucial role in supporting localized energetic and biosynthetic demands [3, 4]

The insertion of insulators into the vector was also shown to decrease vector titer [179], [181]