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The aromatase active site exhibits very high-affinity for exemestane such that the dissociation of exemestane from the aromatase active site occurs very slowly and the association of exemestane with the aromatase active site occurs very fast

doi: 10.1016/j.gene.2012.06.001 94 MalarS.VikramS

doi: 10.1016/j.niox.2014.10.005 39 YangGWuLJiangBYangWQiJCaoKet al

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Cell Cycle 9 , 23052309 (2010)

Integrative analysis pinpointed AKT1 as a central regulatory node: its promoter region was hypomethylated, correlating with increased gene expression and protein phosphorylation