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Amiodarone undergoes extensive hepatic metabolism, is excreted via bile, and has a prolonged half-life (t) of 25 to 110 days

Chlebowski RT, Aragaki AK, Pan K, Simon MS, Neuhouser ML, Haque R, Rohan TE, Wactawski-Wende J, Orchard TS, Mortimer JE, Lane D, Kaunitz AM, Desai P, Wild RA, Barac A, Manson JE (2024) Breast cancer incidence and mortality by metabolic syndrome and obesity: the womens health initiative

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doi: 10.1038/nature12726 220 FurusawaYObataYFukudaSEndoTANakatoGTakahashiDet al