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The investigators found that each 1mg/dL reduction in Lp(a) was associated with a 0.6% decrease in the risk of MACE events.[41] The FOURIER trial found that evolocumab reduced Lp(a) levels by 26.9% and the risk of coronary heart disease, death, myocardial infarction, or urgent revascularization by 23%.[42] Another PCSK9 directed medication is inclisiran, which is a small interfering RNA that blocks PCSK9 messenger RNA

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FDX1 is an important regulator of protein lipoylation The authors identified two mitochondrial proteotoxic stress routes involved in cuproptosis through a genome-wide CRISPR/Cas9 loss-of-function screen

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