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GFAP is a robust marker of cerebrovascular damage and is elevated after repetitive head trauma, reflecting BBB disruption, as seen in contact sport athletes and in individuals with self-reported neurological symptoms in long COVID 26,52,53

Indeed, HGF amplifies angiogenesis after tMCAO in rats and reduces apoptosis in vitro (Shang et al., 2011)

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Importantly, immunohistochemical analyses of human glioblastoma and ex vivo single-cell gene expression profiling of TGF- and HGF confirm the negative interaction between both pathways