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MOTS-c's AMPK activation increases NAD+-dependent processes immediately, but 5-Amino-1MQ's NNMT inhibition takes 90120 minutes to elevate intracellular NAD+ meaningfully

Maintains pool of readily available actin monomers for rapid cytoskeleton reorganization

Dizziness, although rare, is worth noting as it could be a response

[DOI] [PubMed] [Google Scholar] 18.Ellis S., Lin E.J., Tartar D

ClinicalTrials.gov(NCT02500017)

*Correspondence: Shuyu Zhang, [email protected] These authors have contributed equally to this work This article was submitted to Molecular and Cellular Oncology, a section of the journal Frontiers in Oncology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers