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Persistently high levels of ROS lead to oxidative stress, cellular damage, dysfunction, and even cell death [181]

Therefore, the potential effects on offspring when metformin is used by pregnant females with PCOS should be thoroughly evaluated (Nguyen et al., 2018

Open Acc J Envi Soil Sci

Co-transplantation of MSC in the treatment of PD Pereira et al

The NF-B pathway regulates various factors upstream and downstream, further mediating the inflammatory response, oxidative stress response, liver fibrosis, cell apoptosis, autophagy and pyroptosis of liver tissue to promote the process of MASLD (384)