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Similarly, elevated global DNA methylation, Dnmt activity, and 5-methylcytosine but decreased Tet activity and 5-hydroxymethylcytosine were observed in the GSH-deficient hepatocytes and the liver of HFD-fed mice

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Comparatively, oral glutathione pills are considered less effective than injections due to the challenges of absorption during digestion, which may limit their efficacy

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