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Cell 235 LuY.IandievI.HollbornM.KorberN.UlbrichtE.HirrlingerP.et al (2011)

Trust in regenerative medicine is going to depend on whether patients believe the people leading these conversations are being straightforward about both the opportunities and the limitations of the science

introduced a thioketal bond to connect camptothecin [60](CPT) with the photosensitizer 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide a (HPPH), forming a ROS-responsive prodrug (CPT-TK-HPPH)

The location of these mutations suggests that they either act to cause dysregulation in complex I assembly or reduce the enzymatic activity of the enzyme